Effects of the Sesquiterpene Capsidiol on Isolated Guinea-Pig Ileum and Trachea, and on Prostaglandin Synthesis in vitro

Ahmad Nasiri; Anne Holth; Lars Björk

doi:10.1055/s-2006-959652

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Planta Med 1993; 59(3): 203-206
DOI: 10.1055/s-2006-959652

Paper

Effects of the Sesquiterpene Capsidiol on Isolated Guinea-Pig Ileum and Trachea, and on Prostaglandin Synthesis in vitro

Ahmad Nasiri¹ , Anne Holth¹ , Lars Björk¹ ^, ²

¹Department of Pharmacognosy, Biomedical Centre of Uppsala University, P.O.B. 579, S-751 23 Uppsala, Sweden
²Address for correspondence

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Publication History

1992

1992

Publication Date:
04 January 2007 (online)

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Abstract

The sesquiterpene capsidiol (1), isolated from elicited, cultured cells of Nicotiana silvestris (1), inhibits contraction induced by the agonists, histamine, acetylcholine, bradykinin, and barium chloride in the isolated guinea-pig ileum. In addition, capsidiol inhibits contraction induced by histamine and carbachol in the isolated guinea-pig trachea in a nonspecific and non-competitive but concentration-dependent manner. Capsidiol also inhibits prostaglandin synthesis (cyclo-oxygenase) in vitro in a concentration dependent manner.

Key words

Capsidiol - guinea-pig ileum - guinea-pig trachea - prostaglandin synthesis