Subscribe to RSS
Please copy the URL and add it into your RSS Feed Reader.
https://www-thieme-connect-de.accesdistant.sorbonne-universite.fr/rss/thieme/en/10.1055-s-00000004.xml
Download PDF
Aktuelle Neurologie 2010; 37(9): 438-446
DOI: 10.1055/s-0030-1248565
DOI: 10.1055/s-0030-1248565
Neues in der Neurologie
© Georg Thieme Verlag KG Stuttgart · New York
Neues zu Kopfschmerzen 2010
What's New in Headache 2010?Further Information
Publication History
Publication Date:
19 October 2010 (online)
Zusammenfassung
In den letzten Monaten wurden verschiedene innovative Studien veröffentlicht, die maßgeblich zum Verständnis von Kopf- und Gesichtsschmerzen sowie neuropathischen Schmerzen beigetragen haben. Dieser Artikel berichtet über wichtige Forschungsergebnisse, die sich mit verschiedenen epidemiologischen, pathophysiologischen, genetischen sowie therapeutischen Fragestellungen auseinandergesetzt haben. Themenschwerpunkte liegen u. a. auf Triggerfaktoren der Migräne, Therapie und Epidemiologie der chronischen Migräne, Risikofaktoren für vaskuläre Ereignisse bei Migränepatienten, malignes Hirnödem bei Subtypen der Migräne, neue Behandlungsmöglichkeiten in der Akuttherapie (5-HT1F-Agonisten, CGRP-Antagonisten), innovative Applikationsformen für Sumatriptan. Außerdem wird über neue Behandlungsoptionen für trigemino-autonome Kopfschmerzen berichtet. Eine weitere interessante zerebrale Bildgebungsstudie bei posttraumatischen Kopfschmerzen wird vorgestellt, die zeigt, dass schmerzassoziierte Veränderungen der grauen Substanz vermutlich reversibel sind. Die klinische Relevanz der berichteten Studienergebnisse wird beleuchtet.
Abstract
During the last months several innovative studies that contribute to the understanding of headache as well as facial and neuropathic pain have been published. This review highlights important research topics in this field including epidemiology, pathophysiology, genetics and treatment options. Here we summarise, amongst other topics, work on trigger factors in migraine, treatment and epidemiology of chronic migraine, risk of vascular events in migrane patients, malignant brain oedema in subtypes of migraine, new acute treatment options (5-HT1F agonists, CGRP antagonists), and innovative administration forms for sumatriptan. Additionally, the newest insights in the therapy of trigemino autonomic cephalgias are discussed. Interesting neuroimaging data on post-traumatic headache that suggest a reversibility of pain-associated gray matter changes are presented. The clinical relevance of the reported study results is evaluated.
Schlüsselwörter
Kopfschmerzen - chronische Migräne - Pathophysiologie - Therapie
Keywords
headache - chronic migraine - pathophysiology - treatment
Literatur
- 1
Hauge A, Kirchmann M, Olesen J.
Trigger factors in migraine with aura.
Cephalalgia.
2009 [epub ahead of print];
MissingFormLabel
- 2
Natoli J, Manack A, Dean B. et al .
Global prevalence of chronic migraine: a systematic review.
Cephalalgia.
2009 [epub ahead of print];
MissingFormLabel
- 3 Silberstein S D, Lipton R B, Solomon S. et al . Classification of daily or near-daily headaches: proposed revisions to the IHS criteria. Headache. 1994; 34 1-7
- 4 Kurth T, Slomke M A, Kase C S. et al . Migraine, headache, and the risk of stroke in women: a prospective study. Neurology. 2005; 64 1020-1026
- 5 Schurks M, Rist P M, Bigal M E. et al . Migraine and cardiovascular disease: systematic review and meta-analysis. BMJ. 2009; 339 b3914
- 6 Bigal M E, Kurth T, Santanello N. et al . Migraine and cardiovascular disease: a population-based study. Neurology. 2010; 74 628-635
- 7 Kurth T, Ridker P M, Buring J E. Migraine and biomarkers of cardiovascular disease in women. Cephalalgia. 2008; 28 49-56
- 8
Tietjen G E, Brandes J L, Peterlin B L. et al .
Childhood maltreatment and migraine (part III). Association with comorbid pain conditions.
Headache.
2009 [epub ahead of print];
MissingFormLabel
- 9 Tietjen G E, Brandes J L, Peterlin B L. et al . Childhood maltreatment and migraine (part II). Emotional abuse as a risk factor for headache chronification. Headache. 2010; 50 32-41
- 10 Tietjen G E, Brandes J L, Peterlin B L. et al . Childhood maltreatment and migraine (part I). Prevalence and adult revictimization: a multicenter headache clinic survey. Headache. 2010; 50 20-31
- 11 Peterlin B L, Rosso A L, Rapoport A M. et al . Obesity and migraine: The effect of age, gender and adipose tissue distribution. Headache. 2010; 50 52-62
- 12 Bigal M E, Liberman J N, Lipton R B. Obesity and migraine: a population study. Neurology. 2006; 66 545-550
- 13 Bigal M E, Lipton R B. Obesity is a risk factor for transformed migraine but not chronic tension-type headache. Neurology. 2006; 67 252-257
- 14 Mattsson P. Migraine headache and obesity in women aged 40–74 years: a population-based study. Cephalalgia. 2007; 27 877-880
- 15 Bigal M E, Gironda M, Tepper S J. et al . Headache prevention outcome and body mass index. Cephalalgia. 2006; 26 445-450
- 16 Kors E E, Terwindt G M, Vermeulen F LMG. et al . Delayed cerebral edema and fatal coma after minor head trauma: role of CACNA1A calcium channel subunit gene and relationship with familial hemiplegic migraine. Ann Neurol. 2001; 49 753-760
- 17 Stam A H, Luijckx G J, Poll-The B T. et al . Early seizures and cerebral oedema after trivial head trauma associated with the CACNA1A S218L mutation. J Neurol Neurosurg Psychiatry. 2009; 80 1125-1129
- 18 Stewart W F, Wood G C, Manack A. et al . Employment and work impact of chronic migraine and episodic migraine. J Occup Environ Med. 2010; 52 8-14
- 19 Suthisisang C C, Poolsup N, Suksomboon N. et al . Meta-analysis of the efficacy and safety of naproxen sodium in the acute treatment of migraine. Headache. 2010; 50 808-818
- 20 Prior M J, Codispoti J R, Fu M. A randomized, placebo-controlled trial of acetaminophen for treatment of migraine headache. Headache. 2010; 50 819-833
- 21 Anneken K, Evers S, Husstedt I W. Efficacy of fixed combinations of acetylsalicyclic acid, acetaminophen and caffeine in the treatment of idiopathic headache: a review. Eur J Neurol. 2010; 17 534-540
- 22 Ferrari M, Färkkilä M, Reuter U. et al . Acute treatment of migraine with the selective 5-HT1F receptor agonist lasmiditan – A randomized proof-of-concept study. Cephalalgia. , doi DOI: 10.1177/0333102410375512
- 23 Goadsby P J, Edvinsson L. Sumatriptan reverses the changes in calcitonin gene-related peptide seen in the headache phase of migraine. Cephalalgia. 1991; 11 (Suppl. 11) 3-4
- 24 Goadsby P J.
Evidence of the involvement of CGRP in migraine and cluster headache: a physiological perspective. In: Poyner D, Marshall I, Brain S, eds The CGRP Family: Calcitonin Gene-Related Peptide (CGRP), Amylin, and Adrenomedullin. Georgetown, Texas; Landes Bioscience 2000: 159-165MissingFormLabel - 25 Olesen J, Diener H, Husstedt I W. et al . Calcitonin gene-related peptide (CGRP) receptor antagonist BIBN4096BS is effective in the treatment of migraine attacks. N Engl J Med. 2004; 350 1104-1110
- 26 Ho T W, Mannix L K, Fan X. et al . Randomized controlled trial of an oral CGRP receptor antagonist, MK-0974, in acute treatment of migraine. Neurology. 2008; 70 1304-1312
- 27 Connor K M, Shapiro R E, Diener H C. et al . Randomized, controlled trial of telcagepant for the acute treatment of migraine. Neurology. 2009; 73 970-977
- 28 Brandes J L, Cady R K, Freitag F G. et al . Needle-free subcutaneous sumatriptan (Sumavel DosePro): bioequivalence and ease of use. Headache. 2009; 49 1435-1444
- 29 Gillmann P K. Triptans, serotonin agonists, and serotonin syndrome (serotonin toxicity): a review. Headache. 2010; 50 264-272
- 30 Cunnington M, Ephross S, Churchill P. The safety of sumatriptan and naratriptan in pregnancy: what have we learned?. Headache. 2009; 49 1414-1422
- 31 Nezvalova-Henriksen K, Spigset O, Nordeng H. Triptan exposure during pregnancy and the risk of major congenital malformations and adverse pregnancy outcomes: results from the Norwegian Mother and Child Cohort Study. Headache. 2010; 50 563-575
- 32 Olesen C, Steffensen F H, Sorensen H T. et al . Pregnancy outcome following prescription for sumatriptan. Headache. 2000; 40 20-24
- 33 O'Quinn S, Ephross S A, Williams V. et al . Pregnancy and perinatal outcomes in migraineurs using sumatriptan: a prospective study. Arch Gynecol Obstet. 1999; 263 7-12
- 34 Fox A W, Chambers C D, Anderson P O. et al . Evidence-based assessment of pregnancy outcome after sumatriptan exposure. Headache. 2002; 42 8-15
- 35 Fiore M, Shields K E, Santanello N. et al . Exposure to rizatriptan during pregnancy: post-marketing experience up to 30 June 2004. Cephalalgia. 2005; 25 685-688
- 36
Chen H M, Chen S F, Chen Y H. et al .
Increased risk of adverse pregnancy outcomes for women with migraines: a nationwide
population-based study.
Cephalalgia.
2009 [epub ahead of print];
MissingFormLabel
- 37 Lipton R B, Dodick D W, Silberstein S D. et al . Single-pulse transcranial magnetic stimulation for acute treatment of migraine with aura: a randomised, double-blind, parallel-group, sham-controlled trial. Lancet Neurol. 2010; 9 373-380
- 38 Dodick D W, Freitag F, Banks J. et al . Topiramate versus amitriptyline in migraine prevention: a 26-week, multicenter, randomized, double-blind, double-dummy, parallel-group noninferiority trial in adult migraineurs. Clin Ther. 2009; 31 542-559
- 39 Lampl C, Huber G, Adl J. et al . Two different doses of amitriptyline ER in the prophylaxis of migraine: long-term results and predictive factors. Eur J Neurol. 2009; 16 943-948
- 40 Diener H C, Bussone G, Van Oene J. et al . Topiramate reduces headache days in chronic migraine: a randomized, double-blind, placebo-controlled study. Cephalalgia. 2007; 27 814-823
- 41 Diener H C, Dodick D W, Goadsby P J. et al . Utility of topiramate for the treatment of patients with chronic migraine in the presence or absence of acute medication overuse. Cephalalgia. 2009; 29 1021-1027
- 42 Silberstein S D, Lipton R B, Dodick D W. et al . Efficacy and safety of topiramate for the treatment of chronic migraine: a randomized, double-blind, placebo-controlled trial. Headache. 2007; 47 170-180
- 43
Reuter U, Del Rio M S, Diener H C. et al .
Migraines with and without aura and their response to preventive therapy with topiramate.
Cephalalgia.
2009 [epub ahead of print];
MissingFormLabel
- 44
Aurora S, Dodick D, Turkel C. et al .
OnabotulinumtoxinA for treatment of chronic migraine: Results from the double-blind,
randomized, placebo-controlled phase of the PREEMPT 1 trial.
Cephalalgia.
2010;
, first published on March 17, 2010 as doi:
DOI: 10.1177/0333102410364676
MissingFormLabel
- 45
Diener H, Dodick D, Aurora S. et al .
OnabotulinumtoxinA for treatment of chronic migraine: Results from the double-blind,
randomized, placebo-controlled phase of the PREEMPT 2 trial.
Cephalalgia.
2010;
, first published on March 17, 2010 as doi:
DOI: 10.1177/0333102410364677
MissingFormLabel
- 46
Dodick D, Turkel C, DrGryse R. et al .
OnabotulinumA for treatment of chronic migraine: pooled results from the double-blind,
randomized, placebo-controlled phases of the PREEMPT clinical programme.
Headache.
2010; in press;
MissingFormLabel
- 47 Petri S, Tolle T, Straube A. et al . Botulinum toxin as preventive treatment for migraine: a randomized double-blind study. Eur Neurol. 2009; 62 204-211
- 48
Teepker M, Hotzel J, Timmesfeld N. et al .
Low-frequency rTMS of the vertex in the prophylactic treatment of migraine.
Cephalalgia.
2009 [epub ahead of print];
MissingFormLabel
- 49 Schwedt T J, Dodick D W, Hentz J. et al . Occipital nerve stimulation for chronic headache – long-term safety and efficacy. Cephalalgia. 2007; 27 153-157
- 50 Paemeleire K, Van Buyten J P, Van Buynder M. et al . Phenotype of patients responsive to occipital nerve stimulation for refractory head pain. Cephalalgia. 2010; 30 662-673
- 51 Guyuron B, Reed D, Kriegler J S. et al . A placebo-controlled surgical trial of the treatment of migraine headaches. Plast Reconstr Surg. 2009; 124 461-468
- 52
Gaul C, Holle D, Sandor P. et al .
The value of „migraine surgery”: overview of the pathophysiological concept and current
evidence.
Nervenarzt.
2010 Feb 26. [Epub ahead of print] German;
, PubMed PMID 20182856
MissingFormLabel
- 53 Newman L, Mannix L K, Landy S. et al . Naratriptan as short-term prophylaxis in menstrually associated migraine: a randomised, double-blind, placebo-controlled study. Headache. 2001; 41 248-256
- 54 Mannix L K, Savani N, Landy S. et al . Efficacy and tolerability of naratriptan for short-term prevention of menstrually related migraine: data from two randomized, double-blind, placebo-controlled studies. Headache. 2007; 47 1037-1049
- 55 Silberstein S D, Berner T, Tobin J. et al . Scheduled short-term prevention with frovatriptan for migraine occurring exclusively in association with menstruation. Headache. 2009; 49 1283-1297
- 56 Brandes J L, Poole A, Kallela M. et al . Short-term frovatriptan for the prevention of difficult-to-treat menstrual migraine attacks. Cephalalgia. 2009; 29 1133-1148
- 57 MacGregor E A, Brandes J L, Silberstein S. et al . Safety and tolerability of short-term preventive frovatriptan: a combined analysis. Headache. 2009; 49 1298-1314
- 58
Straube A, Pfaffenrath V, Ladwig K H. et al .
Prevalence of chronic migraine and medication overuse headache in Germany – the German
DMKG headache study.
Cephalalgia.
2009 [epub ahead of print];
MissingFormLabel
- 59
Scher A I, Lipton R B, Stewart W F. et al .
Patterns of medication use by chronic and episodic headache sufferers in the general
population: results from the frequent headache epidemiology study.
Cephalalgia.
2009 [epub ahead of print];
MissingFormLabel
- 60 Fontanillas N, Colas R, Munoz P. et al . Long-term evolution of chronic daily headache with medication overuse in the general population. Headache. 2010; 50 981-988
- 61
Sances G, Ghiotto N, Galli F. et al .
Risk factors in medication-overuse headache: a 1-year follow-up study (care II protocol).
Cephalalgia.
2009 [epub ahead of print];
MissingFormLabel
- 62 Cittadini E, May A, Straube A. et al . Effectiveness of intranasal zolmitriptan in acute cluster headache: a randomized, placebo-controlled, double-blind crossover study. Arch Neurol. 2006; 63 1537-1542
- 63 Rapoport A M, Mathew N T, Silberstein S D. et al . Zolmitriptan nasal spray in the acute treatment of cluster headache: a double-blind study. Neurology. 2007; 69 821-826
- 64 Hedlund C, Rapoport A M, Dodick D W. et al . Zolmitriptan nasal spray in the acute treatment of cluster headache: a meta-analysis of two studies. Headache. 2009; 49 1315-1323
- 65 Cohen A S, Burns B, Goadsby P J. High-flow oxygen for treatment of cluster headache: a randomized trial. JAMA. 2009; 302 2451-2457
- 66 Anthony M.
Arrest of attacks of cluster headache by local steroid injection of the occipital nerve. In: Rose FC, ed Migraine: Clinical and Research Advances. London; Karger 1985: 169-173MissingFormLabel - 67 Burns B, Watkins L, Goadsby P J. Treatment of hemicrania continua by occipital nerve stimulation with a bion device: long-term follow-up of a crossover study. Lancet Neurol. 2008; 7 1001-1012
- 68 Magis D, Allena M, Bolla M. et al . Occipital nerve stimulation for drug-resistant chronic cluster headache: a prospective pilot study. Lancet Neurol. 2007; 6 314-321
- 69 Leone M, Proietti C A, Franzini A. et al . Lessons from 8 years' experience of hypothalamic stimulation in cluster headache. Cephalalgia. 2008; 28 787-797
- 70 Leone M, Franzini A, Broggi G. et al . Hypothalamic stimulation for intractable cluster headache: long-term experience. Neurology. 2006; 67 150-152
- 71 Leone M, Franzini A, Broggi G. et al . Hypothalamic deep brain stimulation for intractable chronic cluster headache: a 3-year follow up. J Neurol Sci. 2003; 24 (Suppl. 2) 143-145
- 72 Bartsch T, Pinsker M O, Rasche D. et al . Hypothalamic deep brain stimulation for cluster headache: experience from a new multicase series. Cephalalgia. 2008; 28 285-295
- 73 Fontaine D, Lazorthes Y, Mertens P. et al . Safety and efficacy of deep brain stimulation in refractory cluster headache: a randomized placebo-controlled double-blind trial followed by a 1-year open extension. J Headache Pain. 2010; 11 23-31
- 74
Obermann M, Nebel K, Riegel A. et al .
Incidence and predictors of chronic headache attributed to whiplash injury.
Cephalalgia.
2009 [epub ahead of print];
MissingFormLabel
- 75 Obermann M, Nebel K, Schumann C. et al . Gray matter changes related to chronic posttraumatic headache. Neurology. 2009; 73 978-983
- 76 Cittadini E, Goadsby P J. Hemicrania continua: a clinical study of 39 patients with diagnostic implications. Brain. 2010; 133 1973-1986
- 77 Lanteri-Minet M, Donnet A. Hypnic headache. Curr Pain Headache Rep. 2010; 14 309-315
Prof. Dr. Hans-Christoph Diener
Neurologischen Klinik und Poliklinik
Universität Duisburg-Essen
Hufelandstr. 55
45147 Essen
Email: hans.diener@uni-due.de