Copper(II) Bromide Catalyzed Novel Preparation of Propargylic Ethers and Sulfides by S_N1-Type Substitution between Propargylic Alcohols and Alcohols or Thiols

 

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Abstract

A general and efficient copper(II) bromide catalyzed substitution reaction of propargylic alcohols with carbon and heteroatom-centered nucleophiles, such as alcohols and thiols, leading to the construction of C-O and C-S bonds has been developed. High product yields were obtained with excellent regioselectivity.

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