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Synthesis 2008(7): 1061-1064
DOI: 10.1055/s-2008-1066993
DOI: 10.1055/s-2008-1066993
PAPER
© Georg Thieme Verlag Stuttgart · New YorkStereospecific Synthesis of Functionalized C5-Unsaturated Hydantoin Derivatives via a Three-Component Reaction
Further Information
Received
5 December 2007
Publication Date:
13 March 2008 (online)
Publication History
Publication Date:
13 March 2008 (online)
Abstract
An effective route to functionalized C5-unsaturated hydantoin derivatives is described. This involves the reaction of a urea derivative, derived from the addition of a primary amine to an arylsulfonyl isocyanate, and a dialkyl acetylenedicarboxylate in the presence of isoquinoline.
Key words
primary amine - arylsulfonyl isocyanate - dialkyl acetylenedicarboxylate - hydantoin - isoquinoline - multicomponent reaction
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