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DOI: 10.1055/s-2008-1078004
Pincer-type Ligands for Enantioselective Catalysis
Contributor(s):Hisashi Yamamoto, Joshua P. AbellUniversität Heidelberg, Germany
Chiral Bis(pyridylimino)isoindoles: A Highly Modular Class of Pincer Ligands for Enantioselective Catalysis
Angew. Chem. Int. Ed. 2008, 47: 4670-4674
Publication History
Publication Date:
22 August 2008 (online)
Key words
pincer - iron - hydrosilation - cobalt - cyclopropanation
Significance
In transition-metal catalysis, iron-containing complexes still remain a largely undeveloped field of chemistry. The authors demonstrate a simple, highly modular pincer-derived ligand which showed moderate to high enantioselectivity for iron-catalyzed hydrosilation and cobalt-catalyzed cyclopropanation. The synthesis of the ligand is rather straightforward and this system may have further application in the future.
Comment
Controlling the direction of nucleophilic attack seemed problematic with previously reported pincer-derived ligands. The authors solved this problem by designing a highly modular and tunable ligand which, by X-ray crystal structure analysis, is a distorted octahedral complex. With the highly sterically encumbered pincer ligand the authors were able to control the backside attack of the active site of the catalyst.