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Synfacts 2020; 16(03): 0365
DOI: 10.1055/s-0039-1691658
Flow Chemistry
© Georg Thieme Verlag Stuttgart · New York

Heterogeneous Catalysis in Continuous Flow

Contributor(s):
Hisashi Yamamoto
,
Wataru Muramatsu
Russell MG, Veryser C, Hunter JF, Beingessner RL, Jamison TF. * Massachusetts Institute of Technology, Cambridge, USA
Monolithic Silica Support for Immobilized Catalysis in Continuous Flow.

Adv. Synth. Catal. 2020;
362: 314-319
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Further Information

Publication History

Publication Date:
18 February 2020 (online)

 
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Key words

catalyst support - palladium catalysis - hydrogenation - heterogeneous catalysis - organocatalysis - Mannich reaction

Significance

Heterogeneous catalysis is one of the most economic methods for organic synthesis because the used catalysts are recyclable. The authors have developed two new silicon-based monoliths functionalized with Pd(0) or with a modified Jørgensen catalyst for use in hydrogenation and Mannich reactions, respectively.


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Comment

The hydrogenation and Mannich reactions proceed rapidly and efficiently under flow conditions to afford the corresponding products in satisfactory yields with high stereoselectivities.


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