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Synfacts 2020; 16(03): 0304
DOI: 10.1055/s-0039-1690392
DOI: 10.1055/s-0039-1690392
Metals in Synthesis
Conjunctive Cross-Coupling of Vinyl Boronic Esters
Mega RS,
Duong VK,
Noble A.
*
Aggarwal VK.
* University of Bristol, UK
Decarboxylative Conjunctive Cross-Coupling of Vinyl Boronic Esters Using Metallaphotoredox Catalysis.
Angew. Chem. Int. Ed. 2020;
DOI: 10.1002/anie.201916340
Decarboxylative Conjunctive Cross-Coupling of Vinyl Boronic Esters Using Metallaphotoredox Catalysis.
Angew. Chem. Int. Ed. 2020;
DOI: 10.1002/anie.201916340
Further Information
Publication History
Publication Date:
18 February 2020 (online)
Significance
Aggarwal and co-workers report a metallaphotoredox-catalyzed multicomponent cross-coupling protocol of vinyl boronic esters leading to a broad range of highly functionalized alkyl boronic esters in good to satisfactory yields.
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Comment
This decarboxylative conjunctive cross-coupling was applied in the synthesis of several 1,3-amino alcohols. After separation of both diastereoisomers and simple deprotection, the desired sedum alkaloids were isolated in high yields.
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