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Synfacts 2014; 10(5): 0525
DOI: 10.1055/s-0033-1341222
Metal-Mediated Synthesis
© Georg Thieme Verlag Stuttgart · New York

Copper-Catalyzed α-Amination of Phosphonates and Phosphine Oxides

Contributor(s):
Paul Knochel
,
Thomas Klatt
McDonald SL, Wang Q * Duke University, Durham, USA
Copper-Catalyzed α-Amination of Phosphonates and Phosphine Oxides: A Direct Approach to α-Amino Phosphonic Acids and Derivatives.

Angew. Chem. Int. Ed. 2014;
53: 1867-1871
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Further Information

Publication History

Publication Date:
17 April 2014 (online)

 
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Key words

amination - copper - zinc

Significance

The authors describe the efficient copper-catalyzed α-amination of phosphonates and phosphine oxides using O-benzoyl hydroxylamines. The amination reaction was achieved in good yields at room temperature. A broad scope of functional groups could be tolerated.


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Comment

Currently, the development of an asymmetric α-amination reaction using a chiral catalyst is underway.


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