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Synfacts 2014; 10(3): 0310
DOI: 10.1055/s-0033-1340761
Metal-Mediated Synthesis
© Georg Thieme Verlag Stuttgart · New York

Preparation of a Trifluoromethyl Copper Reagent from Trifluoromethyl Ketones

Contributor(s):
Paul Knochel
,
Diana Haas
Serizawa H, Aikawa K, Mikami K * Tokyo Institute of Technology, Japan
Direct Synthesis of a Trifluoromethyl Copper Reagent from Trifluoromethyl Ketones: Application to Trifluoromethylation.

Chem. Eur. J. 2013;
19: 17692-17697
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Further Information

Publication History

Publication Date:
17 February 2014 (online)

 
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Key words

copper - trifluoromethylation - ketones - boronic acids

Significance

Mikami and co-workers report the preparation of a trifluoromethyl copper reagent which can be employed for the trifluoromethylation of terminal alkynes, aryl boronic acids, and aryl iodides.


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Comment

The use of a low-cost trifluoromethyl source for the preparation of the copper reagent as well as the simple and mild reaction conditions of the trifluoromethylation make this method very interesting for large-scale preparations.


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