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Synfacts 2014; 10(3): 0327
DOI: 10.1055/s-0033-1340719
Polymer-Supported Synthesis
© Georg Thieme Verlag Stuttgart · New York

Pd/Al2O3-Catalyzed Hydrogenation Using H2 Micro- and Nanobubbles

Contributor(s):
Yasuhiro Uozumi
,
Yoichi M. A. Yamada
,
Aya Ohno
Mase N, * Isomura S, Toda M, Watanabe N. Shizuoka University, Hamamatsu, Japan
Micro and Nanobubble Based Strategy for Gas–Liquid–Solid Multiphase Reactions: Palladium-Catalyzed Hydrogenation of Carbon–Carbon Unsaturated Bonds.

Synlett 2013;
24: 2225-2228
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Further Information

Publication History

Publication Date:
17 February 2014 (online)

 
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Key words

hydrogenation - palladium on alumina - micro- and nanobubbles - multiphase reaction

Significance

Mase and co-workers report a gas–liquid–solid multiphase hydrogenation of alkenes and alkynes 1a–g using a hydrogen micro- and nanobubbles (MNBs) introduced flow system. In the presence of Pd/Al2O3 at 30 °C the corresponding hydrogenated products 2a–g are obtained in 93 to >99% yield.


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Comment

The hydrogen MNBs were introduced to the reaction mixture via a MNB generator. The average size of hydrogen MNBs was 158 nm. Experiments with a batch reactor (using a hydrogen balloon, hydrogen bubbling, and an autoclave) were also reported.


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