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Synfacts 2008(12): 1278-1278
DOI: 10.1055/s-0028-1087308
DOI: 10.1055/s-0028-1087308
Synthesis of Materials and Unnatural Products
© Georg Thieme Verlag
Stuttgart ˙ New YorkPolycyclic Isoquinoline Salts
Contributor(s):Timothy M. Swager, Jeewoo LimL. Li, W. W. Brennessel, W. D. Jones*
University of Rochester, USA
An Efficient Low-Temperature Route to Polycyclic Isoquinoline Salt Synthesis via C-H Activation with [Cp*MCl2]2 (M = Rh, Ir)
J. Am. Chem. Soc. 2008, 130: 12414-12419
University of Rochester, USA
An Efficient Low-Temperature Route to Polycyclic Isoquinoline Salt Synthesis via C-H Activation with [Cp*MCl2]2 (M = Rh, Ir)
J. Am. Chem. Soc. 2008, 130: 12414-12419
Further Information
Publication History
Publication Date:
20 November 2008 (online)
Key words
isoquinolines - C-H activation - DMAD
Significance
The authors report efficient syntheses of bi-, tri-, and tetracyclic isoquinoline salts from rhodium and iridium complexes. Isoquinolines are interesting molecules from materials perspective, and this methodology has potential for application in the area.
Comment
Three equivalents of copper(II) chloride were needed for quantitative conversion. While the CuCl3 - salts were not isolated, the authors confirmed the structure of the isoquinolines by treating the reaction mixture with AgBF4 to isolate the products as BF4 - salts.