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Synfacts 2008(12): 1333-1333
DOI: 10.1055/s-0028-1083582
DOI: 10.1055/s-0028-1083582
Organo- and Biocatalysis
© Georg Thieme Verlag
Stuttgart ˙ New YorkA New Bifunctional Catalyst: The Direct Amination of α-Cyanoketones
Contributor(s):Benjamin List, Kristina ZumbansenS. M. Kim, J. H. Lee, D. Y. Kim*
Soonchunhyang University, Chungnam, Korea
Enantioselective Direct Amination of α-Cyanoketones Catalyzed by Bifunctional Organocatalysts
Synlett 2008, 2659-2662
Soonchunhyang University, Chungnam, Korea
Enantioselective Direct Amination of α-Cyanoketones Catalyzed by Bifunctional Organocatalysts
Synlett 2008, 2659-2662
Further Information
Publication History
Publication Date:
20 November 2008 (online)
Key words
electrophilic amination - bifunctional organocatalysts - α-cyanoketones
Significance
A direct α-amination of cyclic and acyclic α-cyanoketones catalyzed by bifunctional organocatalyst 1 with azodicarboxylates as electrophilic nitrogen source is reported. The catalyst amount can be reduced up to 1 mol% without any loss of enantioselectivity.
Comment
The first direct catalytic asymmetric amination of α-cyanoketones using organocatalysts is presented. A new bifunctional organocatalyst possessing a combination of a chiral 1,2-diamine and a binaphthyl scaffold with a thiourea motif has been developed. More applications for this new promising catalyst would be desirable.