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Synfacts 2008(11): 1167-1167  
DOI: 10.1055/s-0028-1083470
Synthesis of Materials and Unnatural Products
© Georg Thieme Verlag Stuttgart ˙ New York

A Ratiometric Turn-on Cobalt Sensor

Contributor(s):Timothy M. Swager, Jan M. Schnorr
W. Lin*, L. Yuan, L. Long, C. Guo, J. Feng
Hunan University, Changsha, P. R. of China
A Fluorescent Cobalt Probe with a Large Ratiometric Fluorescence Response via Modulation of Energy Acceptor Molar Absorptivity on Metal Ion Binding
Adv. Funct. Mater.  2008,  18:  2366-2372  
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Publication History

Publication Date:
23 October 2008 (online)

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Key words

cobalt sensing - ratiometric probes - porphyrins

Significance

The authors present a cobalt sensor exhibiting a large ratiometric fluorescence response. The sensing unit 5 consists of a zinc porphyrin substituted with three coumarin-derived moieties and one cobalt-binding 2,2′-bipyridyl unit. It is obtained via condensation of the aldehydes 1 and 2 with pyrrole and subsequent treatment with zinc acetate.

Comment

The probe is used in the presence of H2O2 to ensure oxidation of paramagnetic Co(II), that would otherwise quench the dye. Under these conditions a very good selectivity for cobalt was achieved [over Sn(II), Fe(III), Mn(II), Hg(II), Cd(II), Zn(II), Na(I), K(I), Mg(II), Ca(II), Ni(II), Al(III), Fe(II)].

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