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Synfacts 2025; 21(07): 711
DOI: 10.1055/a-2606-8183
DOI: 10.1055/a-2606-8183
Metals in Synthesis
Iridium-Catalyzed Enantioselective Hydrogenation of 1,2-Azaborines
Liu J,
Dai Y,
Robinson D,
Li B,
Miqueu K *,
Liu S-Y *.
Boston College, Chestnut Hill, USA, and Université de Pau et des Pays de l’Adour,
Pau Cedex, France
Synthesis of Chiral δ-Aminoboronic Esters by Enantioselective Hydrogenation of 1,2-Azaborines.
Angew. Chem. Int. Ed. 2025;
DOI: 10.1002/anie.202504419
Synthesis of Chiral δ-Aminoboronic Esters by Enantioselective Hydrogenation of 1,2-Azaborines.
Angew. Chem. Int. Ed. 2025;
DOI: 10.1002/anie.202504419
Significance
An iridium-catalyzed protocol for the enantioselective hydrogenation of 1,2-azaborines is reported. This method provides facile access to highly enantioenriched δ-aminoboronic esters.
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Comment
Computational studies revealed that minimization of the steric repulsion between the 1,2-azaborine and the ligand is responsible for the origin of the high stereoselectivity.
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Publication History
Article published online:
23 June 2025
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