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Synfacts 2025; 21(07): 753
DOI: 10.1055/a-2601-5736
DOI: 10.1055/a-2601-5736
Peptide Chemistry
β-Amino Acid Synthesis from Alkylamine and Silylated Alkenes
Thompson MJ,
Yang D,
Higgins JBM,
Schafer LL *.
University of British Columbia, Vancouver, Canada
Regioselective Hydroaminoalkylation with Silylated Alkenes for β-Amino Acid Synthesis.
J. Am. Chem. Soc. 2025;
147: 13415-13423
DOI: 10.1021/jacs.4c18706
Regioselective Hydroaminoalkylation with Silylated Alkenes for β-Amino Acid Synthesis.
J. Am. Chem. Soc. 2025;
147: 13415-13423
DOI: 10.1021/jacs.4c18706
Significance
The β-amino acids, which are unnatural amino acids, and their derivatives are compounds of remarkable versatility. The authors have developed this novel β-amino acid synthesis from simple alkylamines.
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Comment
The hydroaminoalkylation of silylated alkenes was performed with the help of a tantalum catalyst. Further Boc protection and oxidation led to the corresponding β-amino acids.
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Publication History
Article published online:
23 June 2025
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