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Synfacts 2025; 21(07): 752
DOI: 10.1055/a-2601-5212
Peptide Chemistry

Synthesis of Fluorinated Analogues of Amino Acids

Contributor(s):
Hisashi Yamamoto
,
Abhijit Paul 
Iannuzzi M *, Hohmann T *, Dyrks M, Haoues K, Salamon-Krokosz K, Koksch B *. Freie Universität Berlin, Germany
Asymmetric Synthesis of Fluorinated Derivatives of Aromatic and γ-Branched Amino Acids via a Chiral Ni(II) Complex.

Beilstein J. Org. Chem. 2025;
21: 659-669
DOI: 10.3762/bjoc.21.52
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Keywords

fluorinated amino acids - chiral Ni(II) complex - stereoselective synthesis

Significance

Fluorinated amino acids are crucial building blocks in organic synthesis. The authors report here the chiral Ni(II) complex mediated gram-scale synthesis of non-canonical amino acids.


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Comment

This work highlights the remarkable potential of chiral nickel complexes in synthesizing fluorinated amino acids. The ability to generate a diverse array of these compounds from a single starting material is a significant advantage in fluoropeptide chemistry.


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Publication History

Article published online:
23 June 2025

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