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Synfacts 2025; 21(07): 757
DOI: 10.1055/a-2601-4988
Flow Chemistry

In-Flow Oxidation of Primary Alcohols to Carboxylic Acids Using H2O2 and a Pt/SiO2 Catalyst

Contributor(s):
Yasuhiro Uozumi 
,
Ryusei Hoshino
Kon Y *, Nakashima T, Makino Y, Onozawa S-y, Miyamura H, Kobayashi S *, Sato K *. National Institute of Advanced Industrial Science and Technology, Tsukuba and The University of Tokyo, Japan
Continuous-Flow Synthesis of Carboxylic Acids from Alcohols via Platinum and Silicon Dioxide-Catalyzed Hydrogen Peroxide Oxidation.

Org. Biomol. Chem. 2025;
23: 2125-2132
DOI: 10.1039/d4ob01668h
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Keywords

flow reaction - carboxylic acids - primary alcohols - hydrogen peroxide - platinum

Significance

The oxidation of various primary alcohols with H2O2 was performed in flow using a platinum/silica catalyst at 90 °C for 1 hour to give the corresponding carboxylic acids in yields of up to 98 %. Allylic alcohols also underwent the H2O2 oxidation under similar conditions to give the corresponding α,β-unsaturated acids in yields over 60 %.


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Comment

A long-term flow reaction was examined for the oxidation of 1-octanol, where high catalytic efficiency ( > 96 %) was observed over 210 hours.


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Publication History

Article published online:
23 June 2025

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