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Synfacts 2025; 21(07): 755
DOI: 10.1055/a-2601-4377
Peptide Chemistry

Synthesis of Hydroxymates of α-Amino Acids

Contributor(s):
Hisashi Yamamoto
,
Isai Ramakrishna 
Giacomelli G *, Porcheddu A, Salaris M. Università degli Studi di Sassari, Italy
Simple One-Flask Method for the Preparation of Hydroxamic Acids.

Org. Lett. 2003;
5: 2715-2717
DOI: 10.1021/ol034903j
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Keywords

hydroxamic acids - amino acids - cyanuric chloride - hydroxylamine hydrochloride

Significance

Hydroxamic acids are key motifs in organic synthesis and chemical biology, with promising biological activities such as antibacterial, antifungal, antiinflammatory, and anti-asthmatic properties. In this study, the authors developed a cyanuric chloride and NMM-mediated one-step conversion of carboxylic acids into hydroxamic acids under mild conditions.


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Comment

A series of hydroxymates of α-amino acids were synthesized by a cyanuric chloride and NMM-mediated one-step conversion from N-protected amino acids. This is a practically easy, one-pot, and efficient method for the synthesis of hydroxymates of α-amino acids.


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Publication History

Article published online:
23 June 2025

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