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Synfacts 2025; 21(07): 758
DOI: 10.1055/a-2601-4364
Flow Chemistry

Synthesis of Alkyl Azetidines via Batch and Flow Photochemistry

Contributor(s):
Mark Lautens 
,
Mrinmay Baidya
Datsenko OP, Baziievskyi A, Sadkova I, Campos B, Brewster II JT *, Kowalski J, Hinklin RJ *, Mykhailiuk PK *. Enamine Ltd, Kyiv, Ukraine and Pfizer Boulder Research and Development, USA
Alkyl Azetidines Via Batch and Flow Photochemistry.

Org. Lett. 2025;
DOI: 10.1021/acs.orglett.5c00922
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Keywords

azetidines - photocatalysis - decarboxylation - alkyl radicals

Significance

The method offers a practical route to access alkyl azetidines via photochemical decarboxylation of azetidine-2-carboxylic acids. The authors demonstrate excellent scalability and compatibility with flow chemistry for efficient gram-scale synthesis.


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Comment

This scalable photochemical method enables access to diverse alkyl azetidines. The broad scope and subsequent conversion of the products into several heterocyclic derivatives show strong promise for medicinal chemistry applications.


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Publication History

Article published online:
23 June 2025

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