Untersuchungen zur endokrinen Wirksamkeit von Inhaltsstoffen aus Cimicifuga racemosa

H. Jarry; G. Harnischfeger

doi:10.1055/s-2007-969390

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Planta Med 1985; 51(1): 46-49
DOI: 10.1055/s-2007-969390

Research Articles

Untersuchungen zur endokrinen Wirksamkeit von Inhaltsstoffen aus Cimicifuga racemosa

1. Einfluß auf die Serumspiegel von Hypophysenhormonen ovariektomierter RattenStudies on the endocrine effects of the contents of Cimicifuga racemosa:1. Influence on the serum concentration of pituitary hormones in ovariectomized ratsH. Jarry¹ , G. Harnischfeger¹ ^, ²

¹Schaper & Brümmer GmbH, D-3320 Salzgitter-Ringelheim
²Prof. Dr. G. Harnischfeger, Schaper & Brümmer GmbH, Bahnhofstraße 35, D-3320 Salzgitter 61

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Publication History

1984

1984

Publication Date:
26 February 2007 (online)

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Abstract

Endocrine activity can be demonstrated for components of the rhizome of Cimicifuga racemosa using ovariectomized rats as experimental model. A selective reduction of the serum concentration of the pituitary luteinizing hormone (LH) takes place upon application of an extract. The active principle can be concentrated by extraction with dichloromethane. Enzymatic hydrolysis of glucosides leads to a significant loss of endocrine activity in the experimental model system of the ovariectomized rat.