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DOI: 10.1055/s-2002-35229
Synthesis of para-Substituted 3-Formyl Arylboronic Esters
Publication History
Publication Date:
04 November 2002 (online)

Abstract
The synthesis of novel para-substituted amino- and phenoxy-3-formylarylboronic acids is described. These compounds are formed by the hitherto unreported nucleophilic aromatic substitution of fluorine with a range of phenols and amines in the presence of a boronic acid moiety. These reactions proceed in moderate to good yields (37-92%) and provide a useful regioselective synthetic route to trisubstituted arylboronates. These compounds are important both as intermediates in organic synthesis and as end products in their own right.
Keywords
boron - nucleophilic aromatic substitutions - cross-coupling - fluorine
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References
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