Subscribe to RSS
Download PDF
DOI: 10.1055/s-2000-7705
In Vivo Endoscopic Optical Coherence Tomography of Esophagitis, Barrett's Esophagus, and Adenocarcinoma of the Esophagus
Publication History
Publication Date:
31 December 2000 (online)
Background and Study Aims: We studied the feasibility of endoscopic optical coherence tomography imaging in esophageal disorders, including Barrett's esophagus and Barrett-related adenocarcinoma. Optical coherence tomography is a high-resolution cross-sectional imaging technique with a resolution of almost 10 μm.
Patients and Methods: The mucosal architecture of reflux esophagitis (n = 9) and Barrett's esophagus (n = 9) including Barrett-related esophageal cancer (n = 6) was studied by optical coherence tomography imaging.
Results: In different stages of reflux esophagitis edema, fibrinoid deposits, or loss of the epithelial layer were observed. Optical coherence tomography images of Barrett's esophagus substantially differed from normal esophagus, reflux esophagitis, and esophageal carcinoma. A stratified structure of the mucosa was still preserved in Barrett's esophagus. However, images of Barrett-related cancer lacked the regular structure of the esophagus.
Conclusions: The high consistency of the first optical coherence tomography findings, the resolution of up to 10 μm, and the distinct pattern of normal, inflammatory, premalignant and malignant tissues make optical coherence tomography a promising method for endoscopically obtained optical biopsy.
References
- 1 Huang D, Swanson E A, Lin C P, et al. Optical coherence tomography. Science. 1991; 254 1178-1181
- 2 Gelikonov V M, Gelikonov G V, Kuranov R V, et al. Coherent optical tomography of microscopic inhomogeneitis in biological tissues. Pis'ma Zh Eksp Teor Fiz. 1995; 61 149-153
- 3 Kobayashi K, Izatt J A, Kulkarni M D, et al. High-resolution cross-sectional imaging of the gastrointestinal tract using optical coherence tomography: preliminary results. Gastrointest Endosc. 1998; 47 515-523
- 4 Brezinski M E, Tearney G J, Bouma B, et al. Optical biopsy with optical coherence tomography. Ann N Y Acad Sci. 1998; 838 68-74
- 5 Brezinski M E, Fujimoto J G. Optical coherence tomography: high resolution imaging in nontransparent tissue. IEEE J Selected Top Quantum Electronics . 1999; 5 1185-1192
- 6 Tearney G J, Brezinski M E, Bouma B E, et al. In vivo endoscopic optical biopsy with optical coherence tomography. Science. 1997; 276 2037-2039
- 7 Bouma B E, Tearney G J. Power-efficient, non-reciprocal interferometer and linear scanning fibre-optic catheter for optical coherence tomography. Optics Lett. 1999; 24 531-533
- 8 Sivak M V, Kobayashi K, Izatt J A, et al. In vivo high-resolution cross sectional imaging of the human gastrointestinal tract using optical coherence tomography. Gastrointest Endosc. 1999; 49 AB159
- 9 Bouma B E, Tearney G Y, Compton C C, et al. Endoscopic optical coherence tomography of the gastrointestinal tract. Gastrointest Endosc. 1999; 49 AB152
- 10 Brand S, Bouma B E, Tearney G J, et al. Optical coherence tomography (OCT) in the upper gastrointestinal tract. Endoscopy. 1999; 31 E1
- 11 Gelikonov V M, Sergeev A M, Gelikonov G V, et al.
Compact fast-scanning OCT device for in vivo biotissue imaging. In: Conference on lasers and electro-optics. OSA technical digest series. Baltimore, Maryland; Optical Society of America, 1996: 58MissingFormLabel - 12 Sergeev A M, Gelikonov V M, Gelikonov G V, et al. In vivo endoscopic OCT imaging of precancer and cancer states of human mucosa. Optics Express. 1997; 1 432-440
- 13 Feldchtein F I, Gelikonov G V, Gelikonov V M, et al. Endoscopic applications of optical coherence tomography. Optics Express. 1998; 3 257-269
- 14 Jäckle S, Gladkova N, Feldchtein F, et al. In vivo endoscopic optical coherence tomography of the human gastrointestinal tract - toward optical biopsy. Endoscopy. 2000; 32 743-749
- 15 Gladkova N D, Petrova G A, Nikulin N K, et al. In vivo optical coherence tomography imaging of human skin: norm and pathology. Skin Res Technol. 2000; 6 6-16
- 16 Cameron A J, Carpenter H A. Barrett's esophagus, high-grade dysplasia, and early adenocarcinoma: a pathological study. Am J Gastroenterol. 1997; 92 586-591
- 17 Meyer V, Burtin P, Bour B, et al. Endoscopic detection of early esophageal cancer in a high risk population: does Lugol staining improve video endoscopy?. Gastrointest Endosc. 1997; 45 480-484
- 18 Ban S, Toyonaga A, Harada H, et al. Iodine staining for early endoscopic detection of esophageal cancer in alcoholics. Endoscopy. 1998; 30 253-257
- 19 Morales T G, Bhattacharyya A, Camargo E, et al. Methylene blue staining for intestinal metaplasia of the gastric cardia with follow-up for dysplasia. Gastrointest Endosc. 1998; 48 26-31
- 20 Guelrud M, Herrera I. Acetic acid improves identification of remnant islands of Barrett's epithelium after endoscopic therapy. Gastrointest Endosc. 1998; 47 512-515
- 21 Panjehpour M, Overholt B F, Vo-Dinh T, et al. Endoscopic fluorescence detection of high-grade dysplasia in Barrett's esophagus. Gastroenterology. 1996; 111 93-101
- 22 Messmann H, Kullmann F, Wild T, et al. Detection of dysplastic lesions by fluorescence in a model of colitis in rats after previous photosensitization with 5-aminolaevulinic acid. Endoscopy. 1998; 30 333-338
- 23 Adrain A L, Ter H C, Cassidy M J, et al. High-resolution endoluminal sonography is a sensitive modality for the identification of Barrett's metaplasia. Gastrointest Endosc. 1997; 46 147-151
S. Jäckle, M.D.
Dept. of Interdisciplinary Endoscopy University Hospital Eppendorf
Martinistrasse 52
20246 Hamburg
Germany
Fax: Fax:+ 49-40-428032410
Email: E-mail:jaeckle@uke.uni-hamburg.de