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CC BY 4.0 · Arq Neuropsiquiatr 2025; 83(07): s00451809881
DOI: 10.1055/s-0045-1809881
Review Article

Practical issues in the management of sleep, anxiety, and mood disorders in primary headaches

Patrick Emanuell Mesquita Sousa-Santos 
1   Universidade Estadual Paulista, Botucatu SP, Brazil.
,
Mario Fernando Prieto Peres 
2   Universidade de São Paulo, Faculdade de Medicina, Hospital das Clínicas, Instituto de Psiquiatria, São Paulo SP, Brazil.
3   Hospital Israelita Albert Einstein, São Paulo SP, Brazil.
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Abstract

There are many conditions associated with primary headaches, including mood (depression), anxiety, and sleep disorders, which are highly prevalent in the general population and in tertiary headache centers. We call this set of symptoms migraine, anxiety, mood, and sleep (MAMS). The presence of one or more of these symptoms can alter the clinical course and represent a practical challenge. In the present study, we aimed to describe a practical approach to treat these symptoms frequently associated with headaches. Diagnostic aspects and secondary causes were addressed as well as the shared mechanisms and cause and effect relationship. Finally, we commented on the therapeutic approach used to treat these symptoms.

Keywords

Headache Disorders - Migraine Disorders - Sleep Wake Disorders - Anxiety Disorders - Mood Disorders

Authors' Contributions

Conceptualization: PEMSS, MPFF; Data curation: PEMSS; Formal analysis: PEMSS, MPFF; Investigation: PEMSS; Methodology: PEMSS, MPFF; Project administration: MPFF; Supervision: MPFF; Writing – original draft: PEMSS; Writing – review & editing: PEMSS, MPFF.


Editor-in-Chief: Hélio A. G. Teive.https://orcid.org/0000-0003-2305-1073


Associate Editor: Pedro André Kowacs.https://orcid.org/0000-0001-7770-7475




Publication History

Received: 20 October 2024

Accepted: 17 April 2025

Article published online:
02 July 2025

© 2025. The Author(s). This is an open access article published by Thieme under the terms of the Creative Commons Attribution 4.0 International License, permitting copying and reproduction so long as the original work is given appropriate credit (https://creativecommons.org/licenses/by/4.0/)

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Bibliographical Record
Patrick Emanuell Mesquita Sousa-Santos, Mario Fernando Prieto Peres. Practical issues in the management of sleep, anxiety, and mood disorders in primary headaches. Arq Neuropsiquiatr 2025; 83: s00451809881.
DOI: 10.1055/s-0045-1809881
 

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