Spectrum of Typical and Atypical Imaging Findings and Pathological Features in Diabetic Mastopathy

 

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Abstract

Diabetic mastopathy (DMP) is a rare fibroinflammatory condition of the breast seen in patients with diabetes mellitus (DM), which mimics malignancy on imaging. We present eight cases of biopsy-proven DMP with typical (1/8 cases) and atypical (7/8 cases) imaging appearances and describe their histopathological features including duct dilatation/distortion, tight periductal cuffing by inflammatory infiltrates, type of inflammatory infiltrate, stromal fibrosis, epithelial fibroblasts, and grade of lobulitis (mild, moderate, and severe). Our case series depicts the varied atypical imaging findings in DMP and the indispensable role of histopathology in diagnosis. The postbiopsy diagnosis of DM in one of our patients highlights the possible role of histopathology in the detection of patients who may be prone to develop diabetes later. Our series also showed a lack of correlation between the radiopathological findings and clinical features such as duration or type of DM, treatment, and glycemic control status.

Note

Few of the cases in this series were displayed as a part of an educational exhibit on Diabetic Mastopathy at the Annual Conference of Society of Breast Imaging, Maryland, USA, in 2023.

Publication History

Article published online:
04 June 2025

© 2025. Indian Radiological Association. This is an open access article published by Thieme under the terms of the Creative Commons Attribution-NonDerivative-NonCommercial License, permitting copying and reproduction so long as the original work is given appropriate credit. Contents may not be used for commercial purposes, or adapted, remixed, transformed or built upon. (https://creativecommons.org/licenses/by-nc-nd/4.0/)

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