Stereoselective Synthesis of β-Branched Phenylalanine Derivatives via Chelate-Claisen Rearrangement

 

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Abstract

Ester enolate Claisen rearrangement of chelated N-protected chiral amino acid cinnamyl esters results in the formation of substituted phenylalanine derivatives with unsaturated side chains in good yields and with a high degree of chirality transfer.

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