Synthesis of Benzopyrrolizidinones by Norrish-Yang Cyclization of 3-(Acylmethyl)-2-alkylisoindol-1-ones

 

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Abstract

An efficient synthesis of 2-hydroxy-1,2,3,9b-tetrahydropyrrolo[2,1-a]isoindol-5-ones has been achieved by the Norrish-Yang cyclization of 3-(acylmethyl)-2-alkylisoindol-1-ones in benzene in moderate to high yields.

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