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Synthesis
DOI: 10.1055/a-2642-4294
paper

Continuous Flow Telescoped Synthesis of Benzofurans Starting from Nitroalkanes and O-Acetyl Salicylaldehydes

Marino Petrini 
1   Chemistry, University of Camerino, Camerino, Italy
,
Alessandro Palmieri 
2   Chemistry Division, University of Camerino, Camerino, Italy
,
Elettra Gheco
1   Chemistry, University of Camerino, Camerino, Italy
› Author Affiliations
Supported by: European Union - Next-GenerationEU P2022HSF3R
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Herein we report a new practical flow chemical synthesis of benzofurans starting from nitroalkanes and O-acetyl salicylaldehydes. The protocol involves two different sequential steps: (i) an initial base promoted nitroaldol condensation, and (ii) a Nef reaction promoted by tin (II) chloride dihydrate. The target benzofurans are obtained in satisfactory overall yields.



Publication History

Received: 22 May 2025

Accepted after revision: 24 June 2025

Accepted Manuscript online:
24 June 2025

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