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Synthesis
DOI: 10.1055/a-2637-3568
paper

Electrocatalytic Deoxyfluorination of Benzyl Alcohols with SF6 as Fluorinating Agent

Shan Zhu
1   Electric power Research Institute, State Grid Anhui Electric Power Co Ltd, Hefei, China (Ringgold ID: RIN561727)
,
Yue Zhao
1   Electric power Research Institute, State Grid Anhui Electric Power Co Ltd, Hefei, China (Ringgold ID: RIN561727)
,
Fengxiang Ma
2   Electric Power Research Institute, State Grid Anhui Electric Power Co Ltd, Hefei, China (Ringgold ID: RIN561727)
,
Yumei Song
2   Electric Power Research Institute, State Grid Anhui Electric Power Co Ltd, Hefei, China (Ringgold ID: RIN561727)
,
Wei Liu
2   Electric Power Research Institute, State Grid Anhui Electric Power Co Ltd, Hefei, China (Ringgold ID: RIN561727)
,
Jun Cao
2   Electric Power Research Institute, State Grid Anhui Electric Power Co Ltd, Hefei, China (Ringgold ID: RIN561727)
,
Abudu Rexit Abulikemu
3   Institution of Advanced Technology, University of Science and Technology of China, Hefei, China (Ringgold ID: RIN12652)
,
Xisheng Wang 
3   Institution of Advanced Technology, University of Science and Technology of China, Hefei, China (Ringgold ID: RIN12652)
› Author Affiliations
Supported by: Anhui Electric Power Research Institute of State Grid B3120523000Z
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Emerging as the basic structure units in a variety of bioactive molecules, developing straightforward and efficient methods for synthesizing benzylic fluorinated compounds is of considerable significance. Herein, an electrocatalytic strategy utilizing sulfur hexafluoride (SF6) as fluorinating reagent to transform benzylic alcohols into benzyl fluorides has been developed under mild conditions. This reaction is compatible with several substrate backbones and avoids the excessive usage of chemical reductants which provides new routes for the efficient utilization and degradation of SF6, the potent greenhouse gas.



Publication History

Received: 15 April 2025

Accepted after revision: 16 June 2025

Accepted Manuscript online:
16 June 2025

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