Zinc Triflate Catalyzed Tandem One-Pot Regioselective Synthesis of Highly Functionalized Pyrrole Derivatives

 

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Abstract

An efficient, zinc triflate catalyzed, tandem cyclization for the synthesis of highly functionalized pyrrole derivatives of potential medicinal significance has been developed. The four components—an arylamine, an aldehyde, acetylacetone, and nitromethane—were effectively cyclized in a single step with four different bonds (C–C and C–N). The readily available materials, broad substrate scope, excellent functional-group tolerance, mild conditions, scalability, and excellent yields of high-purity products are attractive features of this newly developed protocol.

Publication History

Received: 26 February 2025

Accepted after revision: 07 April 2025

Accepted Manuscript online:
07 April 2025

Article published online:
02 June 2025

© 2025. Thieme. All rights reserved

Georg Thieme Verlag KG
Oswald-Hesse-Straße 50, 70469 Stuttgart, Germany

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