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Planta Med
DOI: 10.1055/a-2536-8919
Reviews

Natural Products Targeting Tau Protein Phosphorylation: A Promising Therapeutic Avenue for Alzheimerʼs Disease

Ziying Chen
1   Science and Technology Innovation Center, Guangzhou University of Chinese Medicine, Guangzhou, China
,
Yan Lu
1   Science and Technology Innovation Center, Guangzhou University of Chinese Medicine, Guangzhou, China
,
Yiyun Wang
1   Science and Technology Innovation Center, Guangzhou University of Chinese Medicine, Guangzhou, China
,
Qi Wang
1   Science and Technology Innovation Center, Guangzhou University of Chinese Medicine, Guangzhou, China
,
Liangwen Yu
1   Science and Technology Innovation Center, Guangzhou University of Chinese Medicine, Guangzhou, China
,
Jinman Liu 
2   Affiliated Jiangmen TCM Hospital of Jiʼnan University, Jiangmen, China
› Author Affiliations
This work was thankfully supported by Science and Technology Innovation Center, Guangzhou University of Chinese Medicine. The research was funded by the China Postdoctoral Science Foundation (Grant no. 2023M741 397), the National Natural Science Foundation of China (Grant no. 82 405 230), Guangdong Basic and Applied Basic Research Foundation (Grant no. 2023A1 515 110 847), and the Key Project of Jiangmen Basic and Applied Basic Research (Grant no.2 320 002 001 026).
› Further Information
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Abstract

Alzheimerʼs disease is a progressive neurodegenerative disorder characterized by tau protein hyperphosphorylation and neurofibrillary tangle formation, which are central to its pathogenesis. This review focuses on the therapeutic potential of natural products in targeting tau phosphorylation, a key factor in Alzheimerʼs disease progression. It comprehensively summarizes current research on various natural compounds, including flavonoids, alkaloids, saponins, polysaccharides, phenols, phenylpropanoids, and terpenoids, highlighting their multitarget mechanisms, such as modulating kinases and phosphatases. The ability of these compounds to mitigate oxidative stress, inflammation, and tau pathology while enhancing cognitive function underscores their value as potential anti-Alzheimerʼs disease therapeutics. By integrating recent advances in extraction methods, pharmacological studies, and artificial intelligence-driven screening technologies, this review provides a valuable reference for future research and development of natural product-based interventions for Alzheimerʼs disease.

Keywords

Alzheimerʼs disease - tau phosphorylation - natural products - glycogen synthase kinase 3β (GSK-3β) - protein phosphatase 2A (PP2A) - neuroprotection


Publication History

Received: 05 December 2024

Accepted after revision: 28 January 2025

Article published online:
14 March 2025

© 2025. Thieme. All rights reserved.

Georg Thieme Verlag KG
Oswald-Hesse-Straße 50, 70469 Stuttgart, Germany

 

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