Propofol up2date – Teil 1: Geschichte und pharmakologische Charakteristika

 

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Propofol ist das am weitesten verbreitete Hypnotikum in der Anästhesiologie und Intensivmedizin und wird auch durch andere Disziplinen für die Sedierung im Rahmen diagnostischer und interventioneller Eingriffe eingesetzt. Trotz seiner Verbreitung sind den Anwendern nicht immer alle pharmakokinetischen und -dynamischen Eigenschaften, Nebenwirkungen und Kontraindikationen dieser facettenreichen Substanz präsent und bezüglich einiger Anwendungsbereiche bestehen Kontroversen und teilweise ungerechtfertigte Vorbehalte. Propofol ist ein hochpotentes Hypnotikum mit einer Vielzahl an (un)erwünschten Nebenwirkungen, die im folgenden Übersichtsartikel zusammengefasst werden sollen.

Propofol is a common hypnotic agent in anaesthesiology and intensive care medicine and for procedural sedation as well. Despite the intensive usage the full potential, pharmacokinetic and –dynamic abilities, interactions and side effects of the substance may not be realized by all providers. Additionally there is dispute and unwarranted myth about the substance. Propofol is a highly potent hypnotic with a wide range of (un)desired effects. This article is reviewing the diversity of the substance in clinical practice.

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